The Hu-M™ CIEA NOG® mouse is generated using human hematopoietic stem cells and the CIEA NOG®(NOD/SCID/IL2R gamma ^null) mouse. These mice develop a functional human immune system and allow for the study of human-specific diseases and novel therapies that target them. HuMurine uses its proprietary isolation and purification technology called the iSCHT™ (isolation of stem cells from primary human tissue) to generate the Hu-M™  CIEA NOG® mouse as a part of its REACH™ (Relevant, Easy to standardize, Addresses current FDA regulatory needs, Cost effective and Highly scalable) platform.

Salient Features of the Hu-M™ CIEA NOG® mouse:

• Reconstituted with hematopoietic stem cells from human fetal liver (up to 50% higher chimerization than cord blood derived cells).
• 8 color FACS validation for human lymphocytes in the PB at 8-12 weeks post engraftment (customer tailored flow matrix).
• Special pricing available for first time customers under exploratory study scheme.
  

The Hu-M™ models can be used as a pre-clinical platform to test therapies against Human:

• Cancer
• Infectious Diseases
• Inflammatory Diseases
• Stem Cell Malignancies
• Cytokine Release Syndrome
• Graft Vs. Host Rejection
• Immunity Assessment
• Vaccine Development
  

The Hu-M™ models are especially useful for testing:

• Efficacy of Antiviral/Antimicrobial drugs and Chemotherapeutics
• Gene therapy applications for safety and efficacy
• Predicting Immune-modulation, Immunogenicity and Lymphotoxicity of INDs
• Embryonic and hematopoietic stem cell maturation and differentiation profiling
• Lymphotoxicity and cytokine release syndrome by monoclonal antibodies/small molecules